A comparison of 5-fluorouracil administered by slow infusion and rapid injection.

نویسندگان

  • C G Moertel
  • A J Schutt
  • R J Reitemeier
  • R G Hahn
چکیده

A comparison of 5-fluorouracil administered by rapid i.v. injection versus 2-hr infusion was conducted in a double-blind study of 149 patients with advanced large bowel cancer. Dosages for each regimen were selected to produce definite but clinically tolerable toxicity. Toxicity pattern, objective response, and symptomatic response were essentially equal with these methods of administration. For practical reasons the rapid injection method is preferred.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pharmacokinetics of 5-fluorouracil administered orally, by rapid intravenous and by slow infusion.

Pharmacokinetic studies of 5-fluorouracil (5-FUra) were performed on 18 patients divided into three groups: seven patients were given 5-FUra i.v. by rapid injection; five patients received the drug p.o.; and six patients were treated by continuous i.v. infusion for 96 hr. The results showed rapid i.v. injection to be manifested by high early levels of drug achieved both in plasma and bone marro...

متن کامل

Induction of general anaesthesia with intraosseous injection of thiopental in rabbits

The technique of intraosseous (IO) infusion has been reemerged as an alternative route of intravascular access for the delivery of fluids and some medications. Complications of IO infusion occur rarely and include fractures and osteomyelitis after long-term use of IO access. The purpose of this study was to compare the efficiency of induction of anaesthesia by a standard intravenous route and a...

متن کامل

Efficacy of 5-Fluorouracil plus Epinephrine, Pulsed Dye Laser and Betamethasone on the Improvement of Psoriatic Plaques (A Comparative Study)

Background: Many efforts are made to find new and more effective treatments for psoriasis. Intralesional 5-Fluorouracil (5-FU) +epinephrine is a cheap option which can be administered with long intervals. The effectiveness of Pulse Dye Laser (PDL) on psoriasis has been already assessed. We decided to evaluate the effectiveness of 5-FU+epinephrine and compare it to betamethasone and PDL.</...

متن کامل

Exposure of family members to antineoplastic drugs via excreta of treated cancer patients.

PURPOSES (a) To measure the urinary excretion of antineoplastic drugs of three patients during 48 h after the administration of cyclophosphamide (two patients) and 5-fluorouracil (one patient). (b) To evaluate environmental contamination with antineoplastic drugs via excreta of patients in the home setting. (c) To evaluate exposure of family members to antineoplastic drugs by measuring the drug...

متن کامل

Oxaliplatin injection for intravenous use

————————————— DOSAGE AND ADMINISTRATION ————————————— • Administer oxaliplatin in combination with 5-fluorouracil/leucovorin every 2 weeks. (2.1): – Day 1: Oxaliplatin 85 mg/m intravenous infusion in 250–500 mL 5% Dextrose Injection, USP and leucovorin 200 mg/m intravenous infusion in 5% Dextrose Injection, USP both given over 120 minutes at the same time in separate bags using a Y-line, follow...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Cancer research

دوره 32 12  شماره 

صفحات  -

تاریخ انتشار 1972